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Journal of Applied Genetics 51(1), 2010, pp. 87-94

Association between α-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis

R. Wang, B. Zhong, Y. Liu, C. Wang

Abstract: Linkage and association studies suggested the relationship between α-adducin polymorphism (Gly460Trp; rs4961) and genetic susceptibility to salt-sensitivity. However, the currently available results were inconsistent. This study aimed to define quantitatively the association between salt-sensitivity and α-adducin Gly460Trp polymorphism in all published case-control studies. Publications from PubMed and other databases were retrieved. The major inclusion criteria were: (1) case-control design; (2) salt-sensitivity confirmed by sodium loading tests, and (3) the distribution of genotypes given in detail. Seven case-control studies fulfilled the inclusion criteria. In total they involved 820 subjects (454 salt-sensitive and 366 non-salt-sensitive). The meta-analysis shows that Gly460Trp polymorphism in general is not significantly associated with salt-sensitivity [OR (95%CI): 1.40 (0.96, 2.04), P = 0.08]. Subgroup analysis showed that the association is statistically significant in Asian people [OR (95%CI):1.33 (1.06, 1.69), P = 0.02] but not in Caucasian people [OR (95%CI):1.98 (0.57, 6.92), P = 0.28]. This indicates that blood pressure response to sodium varies between ethnical groups. More studies based on a larger population are required to evaluate further the role of α-adducin Gly460Trp polymorphism in salt-sensitive hypertension.

Key words: α-adducin, meta-analysis, polymorphism, salt-sensitive hypertension

Correspondence: R. Wang or B. Zhong or C. Wang, Youjiang Medical College for Nationalities, Baise, China and Baylor College of Medicine, Houston, USA; e-mail:;;

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