Journal of Applied Genetics 50(3), 2009, pp. 289-291

Monosomy 10q26-qter and trisomy 11q13-qter as a result of de novo unbalanced translocation

F. Tinsa, Y. Chebbi, M. Meddeb, D. Bousnina, K. Boussetta, S. Bousnina

Abstract: A male infant with partial monosomy 10 q and partial trisomy 11q as a result of de novo unbalanced translocation between the long arms of chromosomes 10 and 11: der(10)t(10;11)(q26;q13) is described. He had craniofacial dysmorphy, congenital heart defects, urogenital and cerebral anomalies, and severe developmental delay. To the best of our knowledge, this is the first report of this combination of chromosomal abnormalities.

Key words: child, monosomy 10q, trisomy 11q

Correspondence: F. Tinsa, Department of Paediatrics of the Children's Hospital of Tunis, Boulevard 9 avril, 1007 Jabbary, Bab Saadoun, Tunis, Tunisia ; e-mail: faten.tinsa@hotmail.fr