Journal of Applied Genetics 50(1), 2009, pp. 69-72

Complex chromosomal rearrangement involving chromosomes 1, 4 and 22 in an infertile male: case report and literature review

Iman Salahshourifar, Niloofar Shahrokhshahi, Tayebe Tavakolzadeh, Zahra Beheshti, Hamid Gourabi

Abstract: Here we describe a rare case of an apparently balanced karyotype of 46, XY, t(1;22;4)(p22.3;q11.1;q31.1) in a infertile male with oligoastenoteratozoospermia (OAT). He was the second patient with complex chromosomal rearrangement (CCR) referred to our center because of infertility. We also review reports on 24 males carrying CCRs with spermatogenesis failure or a malformed child, to provide information on the reproductive outcome of male CCR carriers

Key words: complex chromosomal rearrangements, male infertility, oligoastenoteratozoospermia

Correspondence: I. Salahshourifar, P. O. Box: 19395-4644, Reproductive Genetics Department, Reproductive Medicine Research Center, Royan Institute, ACECR, Tehran, Iran; e-mail: isalahshouri@gmail.com