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Journal of Applied Genetics 48(1), 2007, pp. 93-94

De novo complex chromosomal rearrangement of 46, XY, t (3; 16; 8) (p26; q13; q21.2) in a non-obstructive azoospermic male

Iman Salahshourifar, Mohammad Ali Sedighi Gilani, Ahmad Vosough, Tayebeh Tavakolzadeh, Masoumeh Tahsili, Zahra Mansori, Hamideh Karimi, Mehdi Totonchi, Hamid Gourabi

Abstract: Complex Chromosomal Rearrangements (CCRs) are rare structural abnormalities that are usually associated with infertility or subfertility in male carriers. We described clinical and chromosomal features of a non-obstructive azoospermic male that has been referred for infertility. Cytogenetic analysis showed three chromosomes, i.e. 3, 8 and 16, which have been involved and caused spermatogenesis failure.

Key words: Non-obstructive Azoospermia, Cytogenetic analysis, Complex Chromosomal Rearrangements (CCRs).

Correspondence: I. Salahshourifar, Department of Infertility Genetics, Infertility Clinic & Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran; e-mail:

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