Journal of Applied Genetics 44(2), 2003, pp. 225-229
Inv(10) in a patient with hypogonadotropic hypogonadism - Short communication
Zofia HELSZER, Joanna LACH, Joanna NOWACKA, Maria CONSTANTINOU, Bogdan KALUZEWSKI
Abstract: Hypogonadotropic hypogonadism (HH) was diagnosed in a 22-year-old patient with 46,XY,inv(10) karyotype. It may be associated with some gene mutations of chromosome X, (KAL-1: Kallman syndrome; and DAX-1: congenital adrenal hypoplasia), as well as of certain autosomes, including chromosome 10. This study aimed to: (1) elucidate the aetiopathogenesis of the disease in the studied case: (2) diagnose chromosome aberrations as accurately as possible: and (3) determine if the observed clinical picture can be referred to the diagnosed chromosomal aberration or it is a mere coincidence. The FISH technique, with the use of non-commercial DNA probes, was applied for a precise description of chromosome
Key words: FISH, hypogonadotropic hypogonadism, inv (10), SSCP.
Correspondence: Z. HELSZER, Department of Medical Genetics, Medical University of Lodz, Sterlinga 1/3, 91- 425 Lodz, Poland, e-mail: email@example.com
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