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Journal of Applied Genetics 43(3), 2002, pp. 371-376

Differences between rats and mice in induction of 4S β-naphthoflavone-binding protein expression by treatment with β-naphthoflavone

Damian BRAUZE, Radoslaw JANUCHOWSKI, Krzysztof SZYFTER

Abstract: Sprague-Dawley rats and several inbred strains of mice were compared with respect to the induction of 4S BNF-binding protein expression by treatment with β-naphthoflavone (BNF), an aryl hydrocarbon receptor (AhR) ligand. Inbred strains of mice chosen for the study encompassed 3 allelic forms of AhR found in Mus musculus so far. As it was reported by us earlier, treating rats with BNF caused a significant induction of BNF-binding protein expression. By contrast, no BNF-binding protein was detected in mice treated with BNF in corn oil as a vehicle or with corn oil itself.

Key words: aryl hydrocarbon receptor, 4S β-naphthoflavone binding protein, metabolism of carcinogens.

Correspondence: D. BRAUZE, Institute of Human Genetics, Polish Academy of Sciences, ul. Strzeszynska 32, 60-479 Poznan, Poland. e-mail:

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