JOURNAL OF
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Journal of Applied Genetics 42(2), 2001, pp. 233-235

Influence of diethylenetriamine (DETA) and sodium nitroprusside (NaNP) on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes

Magdalena PERKOWSKA, Magdalena SZCZYGIEL, Agnieszka WOZNIAK, Janusz LIMON


Abstract: Diethylenetriamine (DETA) and Sodium Nitroprusside (NaNP), the exogenous NO-generating compounds, were tested for their genotoxicity in human lymphocytes in vitro using the sister chromatid exchange (SCE) technique. Both compounds were found to be inactive in inducing SCE in concentrations from 0.3 to 30 pM. However both compounds displayed an inhibiting effect on cell kinetics.

Key words: cell cycle kinetics, diethylenetriamine, myocardial ischemia, restenosis, sister chromatid exchange, sodium nitroprusside.

Correspondence: M. Perkowska, Department of Biology and Genetics, Medical University of Gdansk, ul. Debinki 1, 80-211 Gdansk, Poland.