JOURNAL OF
APPLIED GENETICS
        
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Contents



Journal of Applied Genetics 42(1), 2001, pp. 65-71

Human mitochondria in health, disease, ageing and cancer

Ewa BARTNIK, Anna LORENC, Katarzyna MROCZEK


Abstract: In every human cell there are hundreds of mitochondria, which are required for oxidative phosphorylation as well as many other metabolic processes. Each mitochondrion contains approximately 5 mitochondrial DNA molecules. These circular DNAs of 16.5 kb in size contain only 39 genes . Mutations in mitochondrial DNA are responsible for many diseases. Alterations in these molecules may also play a role in ageing and in tumour formation.

Key words: mitochondrial DNA, mutation, tumour

Correspondence: E. Bartnik, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawinskiego 5a, 02-106 Warszawa, Poland, e-mail: ebartnik@ibb.waw.pl.